Welcome to PubChem! Details of the supplier of the safety data sheet Emergency Telephone Number During normal business hours (Monday-Friday, 8am-7pm EST), call (800) 343-0660. General information; Classification & Labelling & PBT assessment; Manufacture, use & exposure generic sorbitan monolaurate, ethoxylated and sorbitan monostearate, ethoxylated are provided in Table 4. Sorbitan stearate is an essential ingredient in many lotions and other skin-care products. Nutritional and pathological effects of sorbitan monolaurate, polyoxyethylene sorbitan monolaurate, polyoxyethylene monolaurate, and polyoxyethylene monostearate when fed to rats Arch Biochem Biophys. It is a non-ionic surfactant with emulsifying, dispersing, and wetting functions. Tween 60. My dough was NOT fermented at all and became really hard like soft plastic! General information; Classification & Labelling & PBT assessment; Manufacture, use & exposure The study was performed using Salmonella typhimurium strains TA98 and TA100 in the presence and absence of S9 metabolic activation system. SECTION 11: Toxicological information 11.1. Polyoxyethylene sorbitan monostearate - Identification, toxicity, use, water pollution potential, ecological toxicity and regulatory information: Note: See Working with the Information on this Page section below for important notes about this data. After normal … This website and underlying databases are maintained and updated by Pesticide Action Network North America (PAN). This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. In developmental toxicity studies of thalidomide, the PEG-20 Sorbitan Laurate vehicle (10 ml/kg) had no effect on the developing embryo. In rabbits, sorbitan monostearate was irritant when applied repeatedly to the skin. Nutritional and pathological effects of sorbitan monolaurate, polyoxyethylene sorbitan monolaurate, polyoxyethylene monolaurate, and polyoxyethylene monostearate when fed to rats. Long-term toxicity study of sorbitan monostearate (Span 60) in mice I don’t want to consume Sorbitan monostearate, the poison might harm our organs especially liver. It acts as a humectant to bind moisture, thicken the product, and stabilize the mixture of water and oils. Sorbitans are a group of compounds derived from sorbitol, a sugar alcohol.8 Joseph Boussin, a French chemist, first isolated sorbitol from berries in 1872.11 Notable sorbitan derivatives include sorbitan sesquioleate (SSO), sorbitan monooleate (SMO), sorbitan monostearate (SMS) and polysorbate.8 SSO is fatty acid ester formed from mono- and diesters of oleic acid and hexitol … The Panel considered that the available reproductive and developmental toxicity studies with sorbitan monostearate have limitations but no adverse effects were reported. Gene mutation toxicity study was performed to determine the mutagenic nature of the test chemical. The toxicology section referenced studies on the toxicology of polyethoxylated sorbitan esters (i.e. In other studies, reproductive and developmental effects were seen primarily at exposure levels that were maternally toxic. Sorbitan monostearate may be safely used as an emulsifier in the following food, sometimes together with polysorbate (60, 65, 80) (1): Whipped edible oil topping; Cakes and cake mixes, icings and fillings; Nonstandardized confectionery coatings and standardized cacao products; Edible vegetable fat-water emulsions in beverage coffee ; It can also be used as a rehydration aid in the … Most important symptoms and effects, both acute and delayed: The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11. Sorbitan monostearate is pure POISON nothing to do with baking! Based on the data available for the test chemical, Sorbitan monostearate, ethoxylated (CAS no 9005 -67 -8) does not exhibit gene mutation in vitro. Hazardous decomposition products Hazardous decomposition products Oxides of carbon. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP … It was of low acute oral toxicity to rats and repeated oral administration affected the kidney, liver and blood of rats and mice, and induced gastrointestinal disturbances in dogs and hamsters. ingram aj et al; short-term toxicity study of sorbitan mono-oleate (span 80) in rats; food cosmet toxicol 16(6) 535 (1978) Hazardous Substances Data Bank (HSDB) 13 Literature In subchronic and chronic oral toxicity studies, PEGs did not cause adverse reproductive effects. EC number: 215-664-9 | CAS number: 1338-41-6 . Hence the test chemical is not likely to classify as a gene mutant in vitro. esters that have been chemically modifed by reacting with the cyclic ether, ethylene oxide, known in the chemical industry as "Tweens"). Information on toxicological effects Toxicological effects Not regarded as a health hazard under current legislation. Of course, I threw that dough away! Test conducted under the static system for 48 hrs. Polyoxyethylene-40-sorbitan monostearate Polysorbate 60 Sorbitan, monooctadecanoate, poly(oxy-1,2-ethanediyl) derivs. Route/Organism Dose Effect Reference; oral/rat : 635 gm/kg (multigenerations) Reproductive: Effects … Acute oral toxicity study of test chemical was conducted on rats at the dose concentration of 60000 mg/kg bw. This stabilization effect is why sorbitan stearate is known as an emulsifier — it allows two liquids, which normally would not blend, to form a stable mix called an emulsion. Sorbitan stearate | C24H46O6 | CID 16218600 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The test chemical was administered via oral unspecified route. The Sorbitan esters, including Sorbitan Stearate, Sorbitan Laurate, Sorbitan Sesquioleate, Sorbitan Oleate, Sorbitan Tristearate, Sorbitan Palmitate, and Sorbitan Trioleate, are used in cosmetic products as emulsifiers and stabilizers at concentrations normally under 5 percent. A 13-week oral repeated-dose toxicity study with CASRN 1338-39-2 in rats showed decreased body weight and significantly increased relative brain and kidney weights (both sexes) at or above 2200 mg/kg-bw/day; a NOAEL for systemic toxicity is not established. Scientific Opinion on the re‐evaluation of polyoxyethylene sorbitan monolaurate (E 432), polyoxyethylene sorbitan monooleate (E 433), polyoxyethylene sorbitan monopalmitate (E 434), polyoxyethylene sorbitan monostearate (E 435) and polyoxyethylene sorbitan tristearate (E 436) as food additives . It is produced from sorbitol and stearic acid, which is a normal fatty acid from vegetable or animal origin.The substance is used in the production of some food and healthcare products. Sorbitan monolaurate 10.6. The acute oral toxicity of the Sorbitan Esters category is low in rats. Even when administered in doses much higher than those that would be ingested in an average diet or from a beauty regimen, sorbitan monostearate is safe for human and animal use. Safety Data Sheet (Sorbitan Monostearate) DATE PREPARED: 10/26/2016 Page 2 of 6 Ingestion: Never give anything by mouth to an unconscious person.Rinse mouth with water. Extensive human and animal testing have show little to no adverse health effects. Sorbitan monostearate (Span 60) is a non-ionic surfactant with emulsifying, dispersing, and wetting properties used as a food additive, additive in mixtures for drug use and in skin care products. Sorbitan monostearate is a waxy powder that is used as an emulsifier that keep water and oils mixed. All animals were maintained under close observation for recording toxic … Consult a physician. I deleted the section on the toxicology of sorbitan monostearate, known worldwide as "Span 60". 1. Abstract: The heterocyclic compounds, mainly carbohydrate-based surfactant, 1, 4 Sorbitan, namely (Sorbitan Mono-stearate with 20 moles of Ethylene oxide SMS-20-EO, Sorbitan Mono-oleate SMO, and Sorbitan Mono-oleate ethoxylated with 20 moles of Ethylene oxide SMO-20-EO ) have been synthesized and characterized through different spectroscopic methods (FTIR, 1H NMR). Uses advised against Food, drug, pesticide or biocidal product use. Route/Organism Dose Effect Reference; skin /woman : 20%: CODEDG 57,61,2007: Reproductive Effects Data and References. Toxicity was reported in subchronic and chronic studies at concentrations above that normally used in cosmetics. Product Name Sorbitan monostearate Cat No. Since the fatty acids used in the production of cosmetic ingredients frequently contain fatty acids other than the principal acid named (ie, a mixture), each of the polysorbates may contain a complex mixture of fatty acid moieties.1,26 Table It is approved for use by FDA in quantities not exceeding the amount reasonably required to accomplish the intended effect. 1951 … based on the data presented in that assessment, the Panel concluded that sorbitan stearate, sorbitan laurate, sorbitan sesqui-oleate, sorbitan oleate, sorbitan tristearate, sorbitan palmitate, and sorbitan trioleate were safe as cosmetic ingredients under [then] present conditions of concentration and use. Short term toxicity of test chemical were studied on the mortality of fish Oryzias latipes (Japanese Medaka). 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